Research Associate (PostDoc) (m / w / d) Experimental Neonatology at the Center for Paediatrics

The University Hospital Bonn is a maximum care hospital with 1,300 beds. Our currently more than 8,000 employees take on tasks in research, teaching and health care at the highest level.

In the working group Experimental Neonatology in the Center for Paediatrics the position of one is as soon as possible

Research Associate (PostDoc) (m / w / d) (Salary group 13 TV-L / 100% - temporary)

to occupy. Employment is initially planned for a period of 2 years as part of a third-party funded project to regulate microglial phenotype expression in an experimental model of perinatal inflammation-sensitized hypoxic-ischemic brain injury.

Our workgroup focuses on damaging events (eg, inflammation, hypoxia-ischemia) in newborns that can permanently adversely affect the developmental processes of the immature brain. Using a variety of experimental models, we investigate underlying pathomechanisms at the cellular and molecular level, with a particular focus on neuron-glia interaction and neuro-inflammatory processes. In addition, the evaluation of potentially cell-protective and neuro-regenerative therapeutic strategies is another major goal of our research.

The project is concerned with the regulation and function of microglial cells in neonatal inflammation-sensitized hypoxic-ischemic brain injury. The focus is on the regulation of different microglial phenotypes and the establishment of neuroprotective therapy options. The in vivo analyzes will be complemented by in vitro experiments with purified cell cultures. Another focus is the establishment of clinically applicable biomarkers, which can be established as part of a clinical trial.

• Autonomous planning and execution of animal studies (infection-sensitized hypoxia-ischemia, hypothermia, behavioral tests) as well as cell biological, proteinbiochemical and molecular-biological investigations in tissues (including immunohistochemistry, Western Blot, PCR)
• Primary cell cultures from tissues
• Immunological Investigations (FACS)
• Imaging / Microscopy (confocal)
• Independent Data Analysis (RNA Sequencing, Proteogenome Analysis)
• Writing scientific publications on an internationally recognized scientific level, presenting research results at conferences

• Doctorate after graduation (master or diploma) in a life sciences or biomedical subject
• Previous knowledge and experience in self-employment in the field of neuroscience is desirable
• Successfully publishing in internationally recognized journals
• Good command of English
• Open-mindedness, reliability and high communication readiness
• Enjoying interdisciplinary work with doctoral students and students
• High level of flexibility and commitment

• Remuneration after TV-L with all services of the civil service (including supplementary and annual special payment)
• Workplace Health Promotion
• The opportunity to purchase a VRS job ticket
• Continuing education and training
• The opportunity to use the company day care center

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. Its aim is to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges relevant qualified women to apply. Applications will be handled in accordance with the National Equality Act. The application of suitable people with proven severe disabilities and those who are treated as such is particularly welcome.