MLU’s academic profile in the field of the humanities is shaped by the core research areas “Enlightenment – Religion – Knowledge” and “Society and Culture in Motion. Diffusion - Experiment - Institution”. The university’s core scientific research is in “Materials Science – Nanostructured Materials” and “Biosciences – Structures and Mechanisms of Biological Information Processing”. Agricultural sciences also play a leading role and Halle’s university bears sole responsibility in Saxony-Anhalt for developing this academic profile. The Faculty of Medicine focuses on epidemiology, health and nursing research and research on signal transmission. Here nursing scientists conduct research on an equal footing with physicians. The Dorothea Erxleben Learning Centre is one of the largest teaching clinics for prospective medical professionals. In addition to its main academic focuses, the university offers a range of minor subjects, some of which are only offered in Germany at MLU.

As a member of the Central German University Alliance Halle-Jena-Leipzig, MLU cooperates closely with other universities, and with external research institutes and industries. This is visible at a local level on the Weinberg Campus, the second largest technology park in Eastern Germany. All of the university’s natural science institutes are concentrated here. They work in partnership with companies and major German research institutes, such as the Max Planck Society and the Fraunhofer-Gesellschaft. Halle’s university has a broad-reaching network of partner universities throughout the world.

In addition to the Weinberg Campus, MLU has three other main locations. The centrally located University Square is one of the most beautiful university squares in Europe and it is a site in Halle that is steeped in tradition. Many institutes focusing on the humanities and social sciences are located on the new Steintor Campus. Educationalists and theologians teach, study and conduct research at the Francke Foundations.